Cabergoline is a dopamine agonist used mainly to lower high prolactin levels. It works by stimulating dopamine receptors in the pituitary gland, which tells the body to cut prolactin production. That makes it a go-to drug for conditions like hyperprolactinemia and prolactin-secreting pituitary tumors (prolactinomas).
When do doctors prescribe it? The most common reason is a prolactinoma causing irregular periods, infertility, or unwanted milk production (galactorrhea). It can shrink small tumors and restore normal hormone levels. Some doctors also use cabergoline off-label for certain Parkinson’s symptoms or to prevent lactation after childbirth, but those uses need careful assessment.
Typical dosing and how to take it
For most people with high prolactin the usual start is 0.25 mg twice a week. Your doctor may raise the dose slowly every few weeks until prolactin is normal or symptoms improve. Dosing for Parkinson’s is different and often higher—only use that under specialist care. You can take cabergoline with or without food. Because it lasts a long time in the body, you don’t take it every day.
Side effects, risks, and what to watch for
Common side effects include nausea, headache, dizziness, tiredness, constipation, and nasal congestion. Dizziness and fainting can happen because cabergoline can lower blood pressure—stand up slowly after sitting or lying down. Some people notice mood changes, sleepiness, or vivid dreams.
There are serious but less common risks. Long-term or high-dose use has been linked with heart valve problems, so doctors may order an echocardiogram if you need treatment for years or at high doses. Cabergoline can also trigger impulse-control issues in a small number of people—things like compulsive gambling or hypersexual behavior. If you notice sudden personality or behavior changes, tell your doctor right away.
Avoid cabergoline if you’re allergic to it or have uncontrolled high blood pressure. It can interact with antipsychotic drugs and medications that block dopamine, making it less effective. Also be cautious if you’re on drugs that lower blood pressure.
Pregnancy and breastfeeding require a talk with your doctor. Many women stop cabergoline once pregnancy is confirmed, unless the tumor is large and causing problems. Your doctor will weigh risks and benefits carefully.
Before you start, expect baseline tests: a prolactin level, pregnancy test if relevant, and sometimes imaging of the pituitary. During treatment your doctor will monitor symptoms and prolactin levels and may check the heart if treatment is long-term.
Bottom line: cabergoline is effective for lowering prolactin and shrinking prolactinomas, but it needs follow-up. Ask questions about dose, side effects, and monitoring. If you feel faint, have chest pain, or notice sudden mood or behavior changes, get medical help quickly.
Tips to reduce side effects: take with food, start at low dose, avoid driving if dizzy, consider anti-nausea meds. If you miss a dose, take it as soon as you remember but don't double doses in the same week—call your doctor for advice. Store cabergoline at room temperature away from light. Buy from licensed pharmacies and never use pills without a prescription—fake meds are common online and can be dangerous. Keep a symptom diary and bring it to appointments.
In a recent blog post, I came across the controversial connection between Cabergoline, a medication used to treat Parkinson's disease, and gambling addiction. Some studies have found that patients taking this medication have experienced compulsive behaviors, including problem gambling. This link raises concerns about the potential side effects of Cabergoline and the need for further research. As a blogger, I believe it's important to keep an open mind and stay informed about such complex issues. Let's continue to explore and discuss these topics to educate ourselves and others.
